As the reigning double world champion on F1's dominant team, Verstappen had already been installed as the favourite but coming into Miami all the indicators were trending in his teammate's direction.
Perez was riding the momentum from a win in Baku and is regarded as an expert on street circuits and tyre management, both factors that would come into play on the 5.41km temporary track around Hard Rock Stadium, the home of the NFL's Miami Dolphins.
But in the end, it was Verstappen who made all the right calls - from tyre selection to race strategy.
Starting ninth on the grid, the Dutchman ripped through the pack and was on pole-sitter Perez's exhaust before the race had reached the midway point.
Perez, who started on medium tyres, pitted first, giving Verstappen an extended run at the front where he squeezed everything he could from his hard tyres before finally stopping for a change with just 11 laps to go.
The stop handed the lead back to his Mexican teammate, but not for long. On fresher tyres, Verstappen was immediately on the prowl and two laps later he was in front of Perez again.
From there it was business as usual, the two Red Bulls easing through the final laps unchallenged for another one-two.
"This is something I wanted already yesterday together with my engineer," Verstappen said of his tyre selection. "We were quite strongly opinionated on that already.
"Then you have to discuss with the team, with the team's interest.
"They were like, 'Okay.'
"But when you start on the hard, the risk is a bit higher because we only had one (set).
"So if you have a ... puncture or whatever, then your race is a bit tougher.
"But I was happy to take that gamble."
Red Bull team principal Christian Horner said that race simulations were against the hard compound but Verstappen and his engineers and strategist wanted to roll the dice.
"Max starting on the hard tyre, there was more risk with that," said Horner.
"Our simulations were telling us it’s actually a worse race but where it potentially gained was if there was a safety car later in the race.
"So his engineering team wanted to take that chance and he made it work without the safety car."
