Claudia MacDonald returns on the left wing after missing top-ranked England's last two games due to injury for the match on Saturday.
Hannah Botterman starts at loose-head prop alongside hooker Amy Cokayne and Sarah Bern in the front row.
"If you see an opportunity to improve or create different pictures that you believe could benefit the team's performance, you have to be brave enough with your selections to make those calls," Middleton said.
"Canada are an opponent we know well with great pedigree and history in the women’s game. We know they are a strong side."
England team:
15 Helena Rowland14 Abby Dow13 Emily Scarratt12 Tatyana Heard 11 Claudia MacDonald 10 Zoe Harrison 9 Leanne Infante
1 Hannah Botterman2 Amy Cokayne 3 Sarah Bern 4 Zoe Aldcroft5 Abbie Ward6 Alex Matthews7 Marlie Packer8 Sarah Hunter
Substitutes: 16 Lark Davies 17 Vickii Cornborough 18 Maud Muir 19 Rosie Galligan 20 Poppy Cleall 21 Lucy Packer 22 Holly Aitchison 23 Ellie Kildunne
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