Brook has notched four centuries and amassed 809 runs in only six tests, flourishing in England's aggressive approach to the game, which has been dubbed 'Bazball' in a nod to coach Brendon McCullum.
He will now try his hand at hitting home runs at the Cardinals camp in Florida as part of a new ambassadorial role with MLB Europe.
"I'm intrigued to see how different it is to cricket and what similarities there are too - will a home run feel as good as hitting a six?" Brook said in an MLB news release on Thursday.
"I'm also excited to learn from how other professional sportspeople go about their game and see if there are any transferable skills between batting in baseball and cricket."
England fast bowler Issy Wong was also named an MLB Europe ambassador.
The Cardinals will face the Chicago Cubs in a two-game series at the London Stadium on June 24 and 25.
