The Springboks front row is hooker Malcolm Marx, and props Louw and Ox Nche. The replacement front row will see hooker Jan-Hendrik Wessels come on with Gerhard Steenekamp and Du Toit.
Lood de Jager and Ruan Nortje remain the lock pairing, with captain Siya Kolisi, Pieter-Steph du Toit and number eight Jasper Wiese in the back row.
Sacha Feinberg-Mngomezulu starts again at flyhalf with Morne van den Berg at scrumhalf, and experienced centres Jesse Kriel and Damian de Allende.
Scrumhalf Cobus Reinach has been brought onto the bench to replace Grant Williams.
The Springboks defeated Italy 66-7 in Turin on Saturday.
"We said from the outset that we would not rotate too much on this tour, so it was always our intention to select a settled squad for this game to build momentum in the competition," coach Rassie Erasmus said.
The Springboks have won the last five matches between the teams in Paris, dating back to 2013.
Nations Championship 2026
The inaugural Nations Championship will see six northern hemisphere and six southern hemisphere nations battle it out across six rounds in the July and November international windows before assembling in Twickenham for one unforgettable finals weekend on November 27-29.
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South Africa team vs France:
Starters: 15-Damian Willemse, 14-Kurt-Lee Arendse, 13-Jesse Kriel, 12-Damian de Allende, 11-Ethan Hooker, 10-Sacha Feinberg-Mngomezulu, 9-Morne van den Berg, 8-Jasper Wiese, 7-Pieter-Steph du Toit, 6-Siya Kolisi (captain), 5-Ruan Nortje, 4-Lood de Jager, 3-Wilco Louw, 2-Malcolm Marx, 1-Ox Nche
Replacements: 16-Jan-Hendrik Wessels, 17-Gerhard Steenekamp, 18-Thomas du Toit, 19-Franco Mostert, 20-Cameron Hanekom, 21-Paul de Villiers, 22-Cobus Reinach, 23-Manie Libbok
