The Austrian gave the 2020 champion Novak Djokovic a huge scare before losing in five sets in a classic final.
Former world number three Thiem later made his Grand Slam breakthrough at that year's US Open.
He struggled with a serious wrist injury the following season but the powerful 29-year-old has been on the comeback trail this year, improving his world ranking to 102 from outside the top 350 in June.
Frenchman Luca Van Assche has also been given a wildcard, while Americans Taylor Townsend and Christopher Eubanks and Frenchwoman Diane Parry were awarded wildcards in the women's tournament.
The four outstanding wildcards - two men and two women - will be awarded next week, organisers said.