In lengthy, and sometimes angry, opening remarks at a news conference on the eve of the start of the tournament, Infantino rounded on European critics of the host nation over the issues of migrant workers and LGBT rights.
He began: “Today I feel Qatari. Today I feel Arabic. Today I feel African. Today I feel gay. Today I feel disabled. Today I feel [like] a migrant worker.
Infantino drew on his own experience as the child of migrant workers growing up in Switzerland, saying he had been bullied for being Italian and for having red hair and freckles.
Of course I am not Qatari, I am not an Arab, I am not African, I am not gay, I am not disabled,” he added. “But I feel like it, because I know what it means to be discriminated [against], to be bullied, as a foreigner in a foreign country. As a child I was bullied – because I had red hair and freckles, plus I was Italian, so imagine.”
Infantino continued: "I am European. For what we have been doing for 3,000 years around the world, we should be apologising for the next 3,000 years before giving moral lessons," he said.
"I have difficulties understanding the criticism. We have to invest in helping these people, in education and to give them a better future and more hope. We should all educate ourselves, many things are not perfect but reform and change takes time.
"This one-sided moral lesson is just hypocrisy," he said.
"It is not easy to take the criticism of a decision that was made 12 years ago. Doha is ready, Qatar is ready and of course it will be the best World Cup ever."
"I know what it feels to be discriminated (against), I know what it's like to be bullied," he said.
"What do you do? You start engaging, this is what we should be doing... The only way of getting results is by engaging.
"I believe the changes that have happened in Qatar would maybe not have happened, or not at least at that speed, (without the World Cup). Obviously, we need to keep pressure, obviously we need to try and make things better."
Infantino also defended the presence of Iran at the tournament despite the current spate of deadly protests there sparked by the death of a woman in police custody in September.
"It's not two regimes playing against each other, it's not two ideologies playing against each other, it's two football teams," he said.
"If we don't have at least football to bring us together... which world are we going to live in? In Iran there are 80 million people, are they all bad? Are they all monsters?"
Addressing Friday's decision to ban the sale of alcoholic beer at stadiums during the tournament, Infantino said FIFA had failed to persuade the Qatar government to stand by the original decision to allow it.
"We tried and that is why I give you the late change of policy," he said. "We tried to see if it was possible."
Infantino said he had received assurances from the highest level of the Qatari government that LGBT people would be welcomed in the country for the World Cup.
Same-sex relations are illegal and punishable by up to three years of jail-time in Qatar. Some soccer stars have raised concerns over the rights of fans travelling for the event, especially LGBT+ individuals and women, whom rights groups say Qatari laws discriminate against.
In an extraordinary end to the news conference, Bryan Swanson, FIFA's director of media relations, took the microphone to defend Infantino.
"I've seen a lot of criticism of Gianni Infantino since I've joined FIFA, in particular from the LGBTI community," he said.
"I'm sitting here in a privileged position on a global stage as a gay man here in Qatar. He has received assurances that everyone will be welcome ... Just because Gianni Infantino is not gay, does not mean he does not care. He does care."