Dybala sustained what Mourinho described as a serious injury in a 2-1 home win over Lecce last month and the Portuguese said it may be difficult for him to return to action before 2023.
Argentina boss Lionel Scaloni is hopeful the striker can still make it to the World Cup in Qatar.
"I don't know his contacts with Argentina and Scaloni. I don't know if he has to play on Sunday to go to the World Cup, or not to play to go to the World Cup," Mourinho said.
Domestic leagues will pause after this weekend's action for the November 20 - December 18 World Cup.
"One thing is obvious. The players who will go to the World Cup are going to have their heads more on the other side than on this side in this last game," Mourinho added.
"Of course we need Paulo. If I have a choice, I would like to have Dybala against Torino."
Argentina, who will announce their 26-man squad on Monday, begin their World Cup campaign on November 22 against Saudi Arabia. They also face Mexico and Poland in Group C.
