Trevor Siemian threw two touchdown passes in the third quarter for the Bears.
Siemian completed 7 of 13 passes for 89 yards in relief of Justin Fields, who went 4 of 7 for 48 yards while running the new offense under coordinator Luke Getsy.
Panthers 23, Commanders 21
Sam Darnold threw for a touchdown and fellow quarterback Baker Mayfield completed 4-of-7 passes for 45 yards as visiting Carolina bolted out to a 20-6 lead before holding off Washington.
Bills 27, Colts 24
Tyler Bass' 46-yard field goal as time expired lifted host Buffalo to a victory over Indianapolis. Bills backup quarterbacks Matt Barkley and Case Keenum combined for 310 passing yards, but they threw no touchdown passes and were intercepted three times. New Colts quarterback Matt Ryan completed 6 of 10 passes for 58 yards.
Steelers 32, Seahawks 25
Kenny Pickett threw a 24-yard touchdown pass to Tyler Vaughns with three seconds remaining, breaking a tie and lifting host Pittsburgh past Seattle. Pickett tossed two TD passes while the Steelers' other two quarterbacks, Mason Rudolph and Mitch Trubisky, threw one scoring pass apiece. Seahawks QB Drew Lock went 11 of 15 for 102 yards and two touchdowns.
Dolphins 26, Buccaneers 24
Jason Sanders' fourth field goal of the game, a 53-yarder with 6:53 to go, gave visiting Miami the lead, and the Dolphins held on for the win over Tampa Bay. With quarterback Tua Tagovailoa sitting out for the Dolphins, Skylar Thompson connected on 20 of 28 passes for 218 yards and a touchdown. QB Tom Brady is away from Buccaneers, and his backups, Kyle Trask (258 passing yards, one interception) and Blaine Gabbert (56 passing yards) each threw a TD pass.
Texans 17, Saints 13
Jeff Driskel's 6-yard touchdown pass to Jaleel Johnson with 25 seconds remaining gave host Houston a win over New Orleans. Driskel finished 16 of 26 for 165 yards with two TD passes and three interceptions. The Saints' Andy Dalton completed all five of his passes for 51 yards and a score.
Rams 29, Chargers 22
Quarterback Bryce Perkins and rookie wide receiver Lance McCutcheon hooked up for two touchdown passes, including the game-winner with 6:11 remaining, to give the Los Angeles Rams a "road" victory over the Los Angeles Chargers. Perkins threw for 133 yards on 10-of-17 passing, while McCutcheon gained 87 yards on five catches. Chargers quarterback Chase Daniel finished 11 of 17 for 117 yards and two touchdowns.
Broncos 17, Cowboys 7
Josh Johnson threw two touchdown passes as host Denver built a 17-0 halftime lead and held on for a win over Dallas. Johnson completed 16 of 23 passes for 172 yards. The Cowboys got a late touchdown pass from Ben DiNucci to Simi Fehoko.
