Ronaldo was linked with Atletico in the transfer window due to his wish to play in the Champions League, but remained at Old Trafford after the deadline for a move passed on September 1st.
Simeone was asked about his side's interest in the forward but the Argentine insisted he was happy with his squad as it is.
"We have a great game to play tomorrow at San Sebastian and that's what where our focus is at," Simeone told a news conference on Friday ahead of their LaLiga match on Saturday at Real Sociedad.
"I think we have a well-balanced team, with the depth to compete at the highest level every week. Now we have to show it on the pitch."
Atletico are sixth in the standings on six points, three behind leaders Real Madrid and Real Betis and one adrift of Barcelona, Villarreal and Athletic Bilbao.
They secured a hard-fought 1-0 win at Valencia thanks to Antoine Griezmann, who came off the bench to score the winner in the second half.
The French forward has been a substitute in all three games so far as reports say Atletico are not keen to pay a 40 million euros clause to Barcelona that would be triggered based on a percentage of matches in which Griezmann plays 30 minutes or more, not including stoppage time.
"You all know me already after ten years as a manager: I'm a club man and always will be," Simeone said when asked if he would keep leaving Griezmann on the bench to avoid triggering the clause.
"I want to try to make you understand that 30 well-played minutes coming off the bench are more important than 60 minutes playing bad.
"Everyone wants to play more minutes but as a coach I need to find the situations that are better as a whole for my team."
