A match that has loomed on the fixture list for months as a likely title-decider now feels like a must-win game for an Arsenal side whose hold on the summit is coming loose.
While treble-chasing City have been churning out the wins, just as they usually do at the business end of a season, Arsenal's young pretenders have been struck by vertigo.
They could have been going to City with a double-digit points lead but after surrendering 2-0 advantages to draw consecutive away games 2-2 at Liverpool and West Ham United, they were then held to a frenzied 3-3 draw by bottom club Southampton on Friday.
After that rip-roaring contest, in which Arsenal needed late goals from Martin Odegaard and Bukayo Saka just to salvage a point, the players slumped to the turf and their fans filed away wondering if the dream of a first title since 2004 was fading.
Arsenal still have a five-point lead with six games to play but City have two matches in hand and look irresistible having collected 25 points from the last 27 on offer.
According to statistician Simon Gleave of data company Gracenote, Arsenal's draw with Southampton left them with a 21% chance of dethroning City, while Pep Guardiola's side now have a 79% probability of finishing top.
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Football has a habit of delivering twists and turns, however, and despite their recent jitters Arsenal remain in a position few could have imagined at the start of the season.
And while Mikel Arteta would have much preferred a bigger cushion heading to the Etihad Stadium, at least his players now know exactly what is required on Wednesday - victory.
"I cannot wait, these are the games you want to play," Arteta said in the wake of Friday's draw. "When everything is at stake you have to go there to win."
It is a big ask though.
Arsenal have lost their last seven meetings with City in all competitions and have not won at City in the league since 2015.
City have chipped away at Arsenal's lead while also progressing to the semi-finals of the Champions League and on Saturday reached the FA Cup final after easing past Sheffield United in third gear.
The games are coming thick and fast for Guardiola's side but such is the quality and depth of his expensively-assembled squad that few doubt their ability to chase only the second treble - Premier League, FA Cup, Champions League - by an English side.
They were able to make six changes to their starting line-up against Sheffield United, while goal-machine Erling Haaland was subbed off early along with Jack Grealish as City set their sights on a classic 'six-pointer' with Arsenal.
Guardiola has not played down what is at stake.
"Wednesday is a final against a team that has been the best team in England so far and is five points ahead of us," the Spaniard said. "It's a massive, important game for us.
"We know winning will give us a step to putting it completely in our hands."
