The Swiss speedster opened up a 140-point lead over Henrik Kristoffersen (28) after claiming his fifth giant slalom victory this season.
The Olympic champion finished 0.23 seconds ahead of Frenchman Alexis Pinturault (31), while Kristoffersen from Norway came third.
Norwegian rival Aleksander Aamodt Kilde (30), who is second in the overall standings, did not participate.
Odermatt now has a overall lead in the World Cup with 486 points over Kilde with five races remaining.
Only Kilde could mathematically beat Odermatt to the overall Crystal Globe but he is not competing in Slovenia this weekend, paving the way for the Swiss skier to wrap up the title after Sunday’s giant slalom.
"Sure, it is another perfect day for me. It was very warm conditions. It wasn’t easy to stay focused at the start. Everything was so soft, so it wasn’t easy to ski. So I am very happy I could win this race," Odermatt said.
