Big-hitting Samsonova secured her 10th straight win with a 6-1 6-3 victory over Belarusian Aliaksandra Sasnovich in Saturday's final.
She will begin her US Open campaign against qualifier Sara Bejlek (16) of the Czech Republic.
The US Open will likely "be a different tournament because the conditions are different there," said Samsonova, who was knocked out in the second round of the hardcourt major last year.
"But of course, I played five matches here, so I think they helped me."
Samsonova's title victory in Cleveland was her second in a row, after she won the Citi Open in Washington DC this month.
"It's unbelievable to win two titles in a row for me here in the United States, I didn't expect it," she said. "I like so much to play here because the surface is pretty fast, I love it. It was helping me in tough situations."
