Stage six was a hilly 129km course from Saint-Die-des-Vosges to Rosheim and Vos' Jumbo Visma team mates positioned themselves on the front with 2km to go.

As the group sprinted to the finish, Vos accelerated and took the lead with 250 metres to go, eventually pipping Italian Marta Bastianelli (35) of UAE Team ADQ by a mere bike length to win the stage.

Vos, who now leads Silvia Persico (25) and Katarzyna Niewiadoma (27) by 30 seconds in the general classification, praised her team for setting up victory.

"In the final (stretch) they did a perfect job to keep me in the front and (kept) the speed high until the last corners, then I was in a good position," Vos said.

"But I felt I was (under pressure) from the back, so I hoped I could keep it until the line... I couldn't excel more but I hoped it was enough."

Lorena Wiebes (23), who won the first and fifth stages, crashed on a descent to fall behind but the Dutchwoman dusted herself off to get back on her bike and catch up despite a cut on her elbow and scrapes on her hip.

Wiebes was one of the favourites to win the stage but the crash meant she eventually finished nearly eight minutes behind, giving Vos a healthy 76-point lead in the green jersey standings as well.

Lotte Kopecky (26) was also involved in the crash but she fought bravely to catch up and eventually finished third.

"Not feeling like I was able to sprint full out. I didn't have the space and had to hold back a few times," she said.

"Too bad, because I could have finished (better) in the results. All went well until I got trapped in the last S-curve."

The last two stages will be in the mountains with Saturday's stage seven a 127.5 km ride from Selestat to Le Markstein Fellering in the Vosges mountains where Annemiek van Vleuten (39) is set to be the favourite.