The 35-year-old wicketkeeper-batter announced in January she was quitting all forms of cricket with the three-match series against India her last in the 50-over format after a storied 16-year career.
She will bid a final farewell in a one-off Test against India starting in Perth on Friday.
Demonstrating that she clearly still has what it takes, Healy crunched 158 off 98 balls in Hobart on Sunday to steer Australia to a bumper 185-run victory and seal the series 3-0.
It was the highest individual score by an Australian woman in ODIs on home soil.
Beth Mooney chipped in with an unbeaten 106.
"What a ridiculous sport that we play, that it can kick you down so many times and then give you opportunities like it has today," Healy told reporters after the game.
"I've hated every milestone match, so this was just an opportunity to go out and enjoy it.
"It was one of the more enjoyable experiences I've had, so thanks to the cricket gods for that, it was a nice way to sign off in the yellow (kit)."
It drew the curtain on a 126-match career that began in 2010, with Healy making 3,777 runs and eight centuries.
