Tandy and his Springbok counterpart Rassie Erasmus have had to send a large number of players back to their clubs. Erasmus will name his team on Thursday.
Blair Murray keeps his place at fullback but has new wingers in Rio Dyer and Ellis Mee, while Joe Roberts partners Joe Hawkins in the centres.
Dan Edwards, who has been impressive this autumn, continues at flyhalf with Kieran Hardy coming in at scrumhalf.
Captain Dewi Lake is at hooker with props Gareth Thomas and Keiron Assiratti, and the locks are Ben Carter and Rhys Davies.
Taine Plumtree, whose father John coaches several of the Springbok players at the Durban-based Sharks, is in the back alongside Alex Mann and Aaron Wainwright.
"What we want to see from the boys is the same type of effort and performance as we did last weekend (a 52-26 loss to New Zealand)," Tandy said. "It’s a great opportunity for the boys. It’s an opportunity for a good few boys to get their start. They’ve all worked hard, excited and can’t wait to get going.
"It’s always a challenge but we’ve had them for 5 or 6 weeks. They are always running our plays and structures. We want to focus on ourselves. With limited numbers you get more intensity. We are always trying to upskill and it isn’t perfect. The boys haven’t played for a while but it's a great opportunity to see where we are."
Some of the Welsh side have been idle for weeks with no United Rugby Championship during the month of November, and will have to hit the ground running.
"You can never replicate playing South Africa," Tandy said. "They get lots of rugby and contact but then there’s top ups on the Friday. Trying to replicate as best we can. We feel we’ve given them the best chance to go out and play. They are so well conditioned.
"Is it perfect? No but I see it as a challenge we have to get over. It’s a good test. It’s just a great opportunity for us."
Tandy admits the depth South Africa have in most positions is daunting.
"They are incredible. You see Rassie how he goes about his selections on the bench. They’ve got two or three teams they can put out. It’s amazing we get to play them. Hopefully we put in a positive performance we can be proud of."
Wales team: 15-Blair Murray, 14-Ellis Mee, 13-Joe Roberts, 12-Joe Hawkins, 11-Rio Dyer, 10-Dan Edwards, 9-Kieran Hardy, 8-Aaron Wainwright, 7-Alex Mann, 6-Taine Plumtree, 5-Rhys Davies, 4-Ben Carter, 3-Keiron Assiratti, 2-Dewi Lake (captain), 1-Gareth Thomas.
Replacements: 16-Brodie Coghlan, 17-Danny Southworth, 18-Chris Coleman, 19-James Ratti, 20-Morgan Morse, 21-Reuben Morgan-Williams, 22-Callum Sheedy, 23-Ben Thomas.
