The Red Devils have been linked to defender Scalvini and midfielder Ederson.
However, any hopes of the club's new investors INEOS being able to secure the duo have been dashed.
According to Sportitalia, Atalanta have informed United the players are not for sale.
The source also adds that it will take at least £52 million to secure Scalvini alone.
Ederson, who is seen as a long-term replacement for Casemiro, has a similar price tag on his shoulders.
