The Red Devils traveled via train to London to take on Tottenham in the Carabao Cup on Thursday.
United are hoping to reach the semi-finals of a competition they won two seasons ago.
Per The Mirror and other outlets, Rashford may well miss this game as well.
The forward was not in the squad for their 2-1 win over Manchester City on Sunday.
He has since given an interview to journalist Henry Winter, outlining his desire to leave.
The 27-year-old is ready to move on from the club where he has been playing since aged 7.
