Sprague, who was named CEO in December 2024, will continue to advise the board and his still-to-be-named successor to ensure a smooth transition, the PGA of America said in a press release.
“At my daughter's wedding last month in upstate New York, it became clear that my family needs me nearby to assist with the care of my mother and mother-in-law," said Sprague.
"Focusing on family has become my priority, and the best decision for me is to step away from my role as CEO and return home to be with them."
The PGA of America, which is a separate organisation from the PGA Tour, runs the PGA Championship, Ryder Cup and many other events.
Sprague, who became a PGA of America member in 1993, served the association in a range of leadership roles, including as a board member from 2008-10 and president from 2014-16.
Prior to being named CEO in 2024, Sprague had served as general manager of TPC Sawgrass - the home of the PGA Tour's flagship event, The Players Championship - in Ponte Vedra Beach, Florida since January 2018.
The PGA of America said it expects to name a new CEO in the coming weeks.
