Free-scoring Juve had won their past two SA games by a three+ goal margin, but in the opening stages they struggled to unlock a Lazio defence that had kept three clean sheets in their previous four away matches.
Their first clear-cut chance came when Gleison Bremer met Kalulu’s 16th-minute cross with a powerful header, but Ivan Provedel brilliantly tipped the ball over the crossbar.
The Lazio goalkeeper was beaten 10 minutes later when Teun Koopmeiners fired into the bottom corner from the edge of the box, only for the goal to be disallowed as Khephren Thuram was standing in an offside position in front of Provedel.
Koopmeiners then flashed another effort just wide from an almost identical position, before teammate Jonathan David headed over from eight yards out.
The contest looked destined to reach the interval goalless, but in first-half stoppage time, Daniel Maldini fed Pedro and the 38-year-old found the net via a big deflection off Bremer to score his third goal of the season, all coming in the past four games.
The Biancocelesti were 45 minutes from a famous victory and they were in dreamland two minutes after the restart when Gustav Isaksen doubled the lead, as the forward raced onto a long ball and lifted his third goal of the campaign into the roof of the net.
Juve’s top goalscorer Kenan Yıldız almost responded immediately with a curling shot from the edge of the box but Provedel dived to his left and clawed the ball away.
Provedel produced another sprawling stop to deny Edon Zhegrova just before the hour mark, but Andrea Cambiaso kept the ball alive and crossed for Weston McKennie to nod home his fourth SA goal of the season.
Kenneth Taylor should have restored Lazio’s two-goal lead when he curled wide from inside the box, before Nuno Tavares produced a goal-saving sliding challenge at the other end to deny Bremer a tap-in.
Yıldız saw another long-range effort saved by Provedel, before the linesman’s flag again denied Juve when McKennie converted from an offside position.
Tijjani Noslin missed a great chance to seal victory when he blazed over late on, and he was made to pay when Kalulu headed home in the sixth minute of stoppage time to preserve Juve’s unbeaten home record in SA this term (W7, D5).
The hosts are now three points above fifth-place Roma as they look to hang on to the final UEFA Champions League qualifying spot, while eighth-place Lazio are now unbeaten in five successive away SA outings (W2).
Flashscore Man of the Match: Ivan Provedel (Lazio)
