Joshua, who lost his WBA, IBF, WBO and IBO heavyweight belts to Ukraine's Oleksandr Usyk in 2021, has won his last three fights as he looks to re-establish himself as a top contender in the division.
"I believe I can knock him out," Joshua told Sky Sports in an interview published on Monday.
"Definitely. I would love to knock him out and make a statement. Physically I feel strong, feeling good. Strong enough to get the job done and mentally I'm in a place where I'm ready for war. I'm looking forward to the challenge.
"Mentally I don't worry so much about my opponent and look at what my opponent can bring to me and think, 'how can I overcome these challenges they present?' I work really hard to up my game and look forward to showing everything I've worked on."
Ngannou vacated his UFC heavyweight belt after a contract dispute with the promotion company and exited as a free agent in January last year. He made his pro boxing debut in October against Tyson Fury, losing via split decision in the non-title fight.
