Arundell, who has six caps as a replacement, comes in for Max Malins (26) - who has scored two tries in 18 internationals - while centre Tuilagi makes his first appearance of the championship in place of the injured Ollie Lawrence (23).
Arundell made one of the more memorable international debuts when he came off the bench to blast through two Australian defenders and score a fantastic try with his first touch in Perth last year.
The London Irish player missed England’s autumn series with a foot injury that required surgery but has been a regular replacement in the Six Nations and scored in the victory over Italy having earned rave reviews on his training performances from his team mates.
Centre Tuilagi, who has won all six of his games against Ireland, makes his first appearance of the championship in place of the injured Ollie Lawrence having served a ban for a red card received playing for Sale.
Farrell replaces Marcus Smith (24), who drops to the bench. That gives England the same Farrell-Tuilagi-Henry Slade combination that last started in the 2019 World Cup quarter-final victory over Australia as they seek to regain pride after the record 53-10 home defeat by France last week.
Despite being overwhelmed at the breakdown in that game, coach Steve Borthwick (43) has kept faith with his pack, the only change being Dave Ribbans (27) replacing injured Ollie Chessum (22) in the second row.
Prop Dan Cole (35) is in line to win his 100th cap from the bench, where Nick Isiekwe (24) and Joe Marchant (26) return.
Ireland are chasing a fifth championship win for a Grand Slam and England are seeking to avoid losing three Six Nations games for the third year in a row.
"We know that after the bitter disappointment of the display against an exceptional France team last week, we will have to be much improved to meet the challenge of playing the side presently ranked number one in the world," Borthwick said.
"However, I have witnessed an England squad determined to make amends for the defeat at Twickenham, and I am confident that the team announced today will once again want to show the sort of resilience and attitude that brought us victory in Wales."
