Vakatawa is suffering from a condition likely to put him at risk playing high-intensity sports, said Racing doctor Sylvain Blanchard, a member of the French League's medical commission, adding that it was first detected in 2019.
"When he was being monitored, it became clear during the last examinations that his pathology had evolved, so much so that cardiological experts were called in to assess the situation," Blanchard said.
"The opinions were unanimous: we should not take the risk of letting him continue to practise high-intensity sports."
Vakatawa, who has Fijian roots, made his France debut in 2016 and has played more than 30 tests. He is only barred from playing in France and it was unclear whether he would try to play abroad.
"It's hard for me to talk in front of everyone," Vakatawa told a news conference.
"I got up at 8 am this morning and I knew I wouldn't be on the pitch. The hardest thing was to tell my teammates yesterday (Monday) that I had to stop playing."
France coach Fabien Galthie (53), who also attended the news conference, was in tears.
"He was a key player in our adventure, in our history, he was great. The last three matches were with us in Japan. He has been great again," he said.
"We have to share this example with our children and tell them to enjoy each match as if it were the last."
