With their final November test against Australia next week, coach Andy Farrell was always likely to make wholesale changes but still named a team with plenty of experience and players likely headed to next year's World Cup.
After an injury ruled Henshaw out the day before the 19-16 win over South Africa, the Leinster man gets a run out ahead of the Wallabies test and will partner Stuart McCloskey, whose impressive start last week was cut short by a first-half knock.
Jimmy O'Brien, who made an assured debut off the bench in place of McCloskey in Saturday's bruising encounter, makes his first start at fullback while Leinster teammate Joey Carbery comes in at flyhalf with Johnny Sexton rested.
The sole debut goes to Munster loosehead Loughman, who was called up to last year's Six Nations squad and traveled on the recent tour to New Zealand. Ulster's Kieran Treadwell and Nick Timoney are also given the chance to impress in an otherwise well-seasoned pack.
Young Munster flyhalf Jack Crowley and Connacht flanker Cian Prendergast look set for their first taste of international rugby off the bench.
Ireland team:
15-Jimmy O'Brien, 14. Robert Baloucoune, 13-Robbie Henshaw, 12-Stuart McCloskey, 11-Mack Hansen, 10-Joey Carbery, 9-Jamison Gibson Park, 8-Jack Conan, 7-Nick Timoney, 6-Caelan Doris, 5-Tadhg Beirne, 4-Kieran Treadwell, 3-Tadhg Furlong (captain), 2-Rob Herring, 1-Jeremy Loughman
Replacements: 16-Dan Sheehan, 17-Cian Healy, 18-Tom O'Toole, 19-Cian Prendergast, 20-Max Deegan, 21-Craig Casey, 22-Jack Crowley, 23-Garry Ringrose
