Argentina were unfortunate to lose 22-21 when the teams met in Johannesburg last weekend as they dominated possession and matched the home side physically, but were unable to finish off their numerous entries into the Springboks' 22-metre line.
The other four changes are all in the backline.
Full back Juan Cruz Mallia (26) has been cited for a dangerous piece of play, having clattered into the head of Bok scrumhalf Grant Williams after only 11 seconds last week in an attempt to charge down a kick.
The outcome of that hearing has not been released by officials, but Mallia has not been included in the matchday 23.
Boffelli’s return boosts the home side’s goal-kicking, with fly half Santiago Carreras (25) missing three relatively simple shots at goal last week that proved very costly.
Santiago Cordero (29) replaces Juan Imhoff (35) on the other wing, while the final change sees Gonzalo Bertranou (29) come in at scrum half for Lautaro Bazan Velez (27).
Hooker Augustin Creevy (38) could be the first Argentine player to reach 100 caps if he comes off the replacement's bench.