Fleetwood was born in Southport, around 30 miles north of Royal Liverpool, and the world number 21 would be a popular champion after a couple of near-misses.
"It's nice to have a week that feels so close to home," Fleetwood told reporters on Wednesday. "Course is great. It's changed a lot since the last Open (in 2014)."
He finished second in the 2019 Open at Portrush and tied fourth 12 months ago at St Andrews.
"As soon as the week starts you start sort of feeling The Open atmosphere, which you always think is very, very cool," Fleetwood said.
"I've imagined winning it about a million times probably. Winning a major is a dream, winning The Open is a huge, huge dream. Having the opportunity to do it so close to where you grew up is something that's very unique and very special."
Fleetwood will play the first two rounds at Hoylake with American world number one Scottie Scheffler (23) and Australian Adam Scott (43), both former Masters champions.
"I get on with both guys very, very well. I enjoy being around them. I enjoy playing golf with them. It's a really nice three-ball for me," he said.
"I was very happy with the guys that I'm playing with. Great golfers, both very good at winning tournaments," Fleetwood added.
"It's always good to be around those people that are at the top of the game and make sure you're always trying to keep pace with them."
