The Swiss speedster also opened an unassailable 586-point lead at the top of the overall standings over second-placed Aleksander Aamodt Kilde (30) of Norway who did not participate in the races this weekend.
The season will wrap up with four events in Soldeu, Andorra, next week.
Odermatt finished the race in two minutes 20.91 seconds, 0.32 seconds ahead of Henrik Kristoffersen (28) from Norway. French skier Alexis Pinturault (31) came in third.
"It’s a little bit different, I guess - last year I was way more nervous," said Odermatt after the second title.
"This weekend was a little more calm, I already had a globe at home, and had a little advantage with the points, so it was a bit more relaxed."
Odermatt can break the overall point records next week as he only needs 175 to beat the greatest individual men’s season points of 2,000, set by Austrian Herman Maier in 2000.
