Borussia Monchengladbach striker Marcus Thuram (25) and Monaco defender Axel Disasi (24) were called up as Deschamps completed his squad, the French federation said on Monday.
Disasi made the final cut after Kimpembe ruled himself out because of a hamstring injury.
"Kimpembe did not have all the elements to be ready," Deschamps told reporters on Monday.
"He is honest and faces reality even though it's painful."
Asked about his options to replace Kimpembe, the France coach added: "Konate and Upamecano. I already know what I will do against Australia."
Deschamps also said Manchester United centre back Raphael Varane (29), who has been included in the squad despite being injured in October, was making good progress.
"He is training with the ball and doing well," Deschamps said. "He still has steps to take in the next few days. He is fine. He is in good spirits.
"We are not going to cut corners. He is supposed to be available for the first game."
France kick off their Group D campaign against Australia on November 22 before facing Denmark four days later and Tunisia on November 30.
