Kinghorn missed their first two championship games – a narrow win in Wales and a controversial home loss to France – with a knee injury, forcing coach Gregor Townsend to play regular wing Kyle Rowe and uncapped Harry Paterson at number 15.
Following the retirement of Stuart Hogg last year, Kinghorn, who has 50 caps, has been a stand-out performer for the Scots and the experience of the Toulouse back is a big boost for Townsend.
Steyn pulled out of the match against France on the day after his wife went into labour, and will partner fellow wing Duhan van der Merwe and Kinghorn in a potent back three that will provide plenty of threat to the visitors.
Sione Tuipulotu and Huw Jones retain their centre partnership, while co-captain Russell is alongside scrumhalf Ben White, who has been in outstanding form this season.
There is one switch in the forwards as former skipper Jamie Ritchie returns to the side of the scrum. He forms a back row with co-captain Rory Darge and number eight Jack Dempsey.
Hooker George Turner packs down with props Pierre Schoeman and Zander Fagerson either side of him, while Grant Gilchrist and Scott Cummings make up the second row as Scotland seek a fourth successive victory over old foes England.
Scotland team:
15-Blair Kinghorn, 14-Kyle Steyn, 13-Huw Jones, 12-Sione Tuipulotu, 11-Duhan van der Merwe, 10-Finn Russell, 9-Ben White; 1-Pierre Schoeman, 2-George Turner, 3-Zander Fagerson, 4-Grant Gilchrist, 5-Scott Cummings, 6-Jamie Ritchie, 7-Rory Darge, 8-Jack Dempsey
Replacements: 16-Ewan Ashman, 17-Alec Hepburn, 18-Elliot Millar-Mills, 19-Sam Skinner, 20-Andy Christie, 21-George Horne, 22-Ben Healy, 23-Cameron Redpath
