Coach Kieran Crowley (62) has reverted back to almost the same side which defeated Namibia, which sees Paolo Garbisi (23) back at fly half, Tommaso Allan (30) in the full back position and winger Ange Capuozzo (24) as part of their attacking backline selection.
The only change from that opening 52-8 win over Namibia sees prop Marco Riccioni (25), who played in the victory over Uruguay, in for Simone Ferrari (29).
"As against previous opponents, the focus will be on our performance. Accuracy and discipline will be key," Crowley said.
"We will face this game with courage and continue to consolidate our identity."
Lamb, who scored a try against Namibia, slots back in for Niccolo Cannone (25) who drops to the bench after the Uruguay win, scrum half Varney returns in place of Alessandro Garbisi (21), and Morisi is back at centre.
Italy are currently in second place in Pool A, with 10 points, three points behind France and five ahead of the All Blacks. A surprise win over New Zealand would see Italy reach the knockout stages of the World Cup for the first time.
The two sides have met on 15 occasions, and New Zealand have won them all.
Italy still have one more game after this, when they face hosts France, again in Lyon, on October 6th.
