AFP Sport looks at where each of the contenders stand and how their run-ins compare.
Arsenal - 64 points
The Gunners are the most in-form of the three contenders with a run of eight consecutive league wins in 2024, including a crucial 3-1 victory over Liverpool in January.
Mikel Arteta's men have smashed in 33 goals in those eight games to also open up a healthy goal difference advantage over their rivals, which could prove decisive.
Arsenal are not in league action again for another three weeks and their trip to City on March 31st is the acid test of how much they have improved over the last 12 months.
Arteta's young side were thrashed 4-1 at the Etihad last season as they stumbled down the home straight in the title race after leading for much of the season.
A year on they look more mature and have a deeper squad to cope with the pressure of trying to win a first title in 20 years.
Summer signings Declan Rice and Kai Havertz were the goalscorers for a nervy 2-1 win over Brentford on Saturday that tested their mettle as Havertz's winner arrived just four minutes from time.
But a series of tough away games lie ahead, even after their daunting trip to City.
Arsenal are still to face north London rivals Tottenham, Manchester United, Brighton and Wolves on the road.
Fixtures to come:
March 31st: Manchester City (A)
April 3rd: Luton (H)
April 6th: Brighton (A)
April 13th: Aston Villa (H)
April 20th: Wolves (A)
April 27th: Tottenham (A)
May 4th: Bournemouth (H)
May 11th: Manchester United (A)
April 19th: Everton (H)
Liverpool - 64 points
Jurgen Klopp's men failed to make their second-half supremacy count in a pulsating 1-1 draw against City on Sunday.
However, the Reds have on paper the kindest run-in as they aim to send off their manager in style at the end of the season.
Klopp has kept Liverpool on track for a potential quadruple despite an injury crisis that would have derailed a title challenge at other clubs.
Alisson Becker, Trent Alexander-Arnold and Diogo Jota remain sidelined, but Klopp is beginning to get some of his other key players back.
Mohamed Salah has come off the bench in the last two games, while Dominik Szoboszlai and Darwin Nunez started against City.
But Liverpool have to balance their title challenge with a deep run into the Europa League and FA Cup.
They travel to Manchester United next weekend in the FA Cup quarter-finals and face another trip to Old Trafford in the league next month.
A local derby away to Everton could also prove tricky, while they also Champions League-chasing Tottenham and Aston Villa in two of their final three games.
Fixtures to come:
March 31st: Brighton (H)
April 4th: Sheffield United (H)
April 7th: Manchester United (A)
April 14th: Crystal Palace (H)
April 20th: Fulham (A)
April 27th: West Ham (A)
May 4th: Tottenham (H)
May 11th: Aston Villa (A)
May 19th: Wolves (H)
TBC: Everton (A)
Manchester City - 63 points
City are aiming to become the first side to ever win four consecutive English top-flight titles and have know-how on their side of getting over the line.
Pep Guardiola admitted his side had survived a Liverpool "tsunami" to escape Anfield with a point that leaves them still well in the hunt.
The defending champions are midway through a defining month with fourth-placed Villa to visit the Etihad three days after Arsenal.
But should they remain in striking distance in early April, City will be confident of reeling in the leaders with a trip to Tottenham on paper the only tricky fixture in their final eight games.
Fixtures to come:
March 31st: Arsenal (H)
April 3rd: Aston Villa (H)
April 6th: Crystal Palace (A)
April 13th: Luton (H)
April 20th: Tottenham (A)
April 27th: Nottingham Forest (A)
May 4th: Wolves (H)
May 11th: Fulham (A)
May 19th: West Ham (H)
TBC: Brighton (A)
