A total of 50 regular season NFL games have been played internationally so far, with Madrid becoming the fourth European city to host one after London, Munich and Frankfurt.

"The National Football League's arrival at the Santiago Bernabeu is a major event in sport history," said Real Madrid President Florentino Perez.

"This strategic alliance... will boost our brands globally. It will be enthusiastically welcomed by millions of people on all continents, and it is an honour to embark on this journey together."

Sao Paulo will stage the first such game in South America in 2024 at the Corinthians Arena, home to Brazil's Corinthians.

In 2023, the NFL clubs voted to increase league-operated international game inventory from four to up to eight a season beginning in 2025.